Römer T - Researchers performed a retrospective, practice-based study determining the efficacy and safety of dienogest in women with endometriosis treated for at least 60 months. Dienogest was begun after laparoscopy in 22 women; median EAPP score was 70 mm pre-surgery and 10, 10, 20, 20, and 20 mm, respectively, after 12, 24, 36, 48, and 60 months of dienogest treatment. Dienogest was begun in another 15 women without prior surgery; median EAPP score was 80 mm pretreatment and 20, 20, 30, 30, and 30 mm, respectively, after 12, 24, 36, 48, and 60 months. This suggests that the treatment is effective in reducing endometriosis-associated pelvic pain (EAPP) and avoiding pain recurrence post-surgery. The patients well-tolerated dienogest and had adverse effects that were clinically managed.