Fretland AA, et al. - In a randomized controlled trial (OSLO-COMET), researchers compared laparoscopic vs open liver surgery with respect to postoperative morbidity within 30 days in patients with radically resectable liver metastases from colorectal cancer. A predefined secondary endpoint for the trial was overall survival. A total of 133 patients received laparoscopic surgery and 147 received open surgery. A significant attenuation in morbidity, from 31% in the open group to 19% in the laparoscopic group, was shown by the primary endpoint. The groups did not differ in terms of other secondary outcomes, including the rate of R0 resection and the width of resection margins, while cost-efficacy of laparoscopic surgery was reported. With regard to rates of overall survival and recurrence free survival, similar outcomes were provided by laparoscopic surgery vs open surgery in patients with colorectal liver metastases.