Long-term risks of Parkinson disease, surgery, and colorectal cancer in patients with slow-transit constipation
Clinical Gastroenterology and Hepatology Sep 04, 2020
Song EM, Lee HJ, Jung KW, et al. - This study was undertaken to explore the incidences of Parkinson’s disease, constipation-related surgery, and colorectal cancer (CRC) in patients with constipation and slow-transit constipation (STC), followed for up to 20 years. Between 2000 and 2010, data were obtained from 2,165 patients (33.1% men; median patient age, 54 years; median symptom duration, 5.0 years) with a diagnosis of constipation (based on Rome II criteria) who underwent anorectal function test and a colonic transit time study, at a tertiary university hospital in Seoul, South Korea. The Kaplan-Meier method was applied to evaluate and compare the cumulative probabilities of a new diagnosis of Parkinson’s disease or CRC according to the presence of STC. Researchers found that most of the patients had no severe complications in a long-term follow-up study of patients with constipation in Korea. Nevertheless, for Parkinson’s disease screening, individuals older than 65 years with a new diagnosis of STC can be considered.
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