Morin SN, Yan L, Lix LM, et al. - In view of the observations indicating an increased risk of subsequent fractures following an index fracture, and its decline over time, researchers herein examined if this risk was sustained over 25 years and determined its evolution by gender.

• Data of a total of 16,876 men and 39,230 women ≥ 50 years, who sustained an index fracture during 1989–2006, were retrieved using population-based databases for performing this cohort study.

• Findings suggest that both men and women, who sustain an index fracture, remain at increased risk of subsequent major osteoporotic and hip fracture over 25 years, with modest time-dependent attenuation.

• Men were noted to be at the highest risk, highlighting the relevance of targeted treatment strategies particularly in this under-treated population.