Giang KW, Hansson PO, Mandalenakis Z, et al. - This study was sought to ascertain if systolic blood pressure reactions during exercise have any prognostic value relative to the long-term risk of stroke and myocardial infarction (MI). Researchers assessed a representative cohort of men from Gothenburg, Sweden who were born in 1913, in whom a maximum exercise test was conducted at age 54 years, (n = 604) and were followed-up for a maximum of 44 years in terms of stroke and MI. An elevated risk of stroke was seen among middle-aged men with high resting and maximum blood pressure during maximum exercise workload, but one was not seen for MI . Further trials with larger sample sizes are required to evaluate the underlying mechanisms of the elevated risk of stroke among individuals with hypertensive response to exercise. For maximum SBP, the risk of stroke increased by 34% per 1-SD increase. Men with a resting SBP of at least 140 mmHg and a maximum SBP of at least 210 mmHg had the highest risk of stroke vs men with a resting SBP of less than 140 mmHg and a maximum SBP of less than 210 mmHg, independent of smoking, blood glucose, cholesterol and BMI.