Rocca WA, et al. - A cohort study of women who underwent bilateral oophorectomy prior to menopause for a noncancer indication from 1950 through 1987 was conducted to assess the long-term risk of depressive and anxiety symptoms in these patients. They matched each member of the bilateral oophorectomy cohort, by age, with a woman who had not undergone an oophorectomy. Findings revealed an increased long-term risk of depressive and anxiety symptoms in correlation to bilateral oophorectomy performed before the onset of menopause. Greater associations were noted with younger age at oophorectomy. However, indications for the oophorectomy did not influence the associations. In addition, the risk did not modify with estrogen treatment to age 50 years in these women.