Raj A, Salvador-Culla B, Anwar H, et al. - By performing this single-center, retrospective review, researchers investigated the incidence, demographics, management, as well as results of topical steroid-induced ocular hypertension following penetrating keratoplasty (PKP). They also determined influences on intraocular pressure (IOP) and graft rejection when alternate corticosteroids were used. There were 568 consecutive PKPs done between 1997 and 2010. This study included 80 eyes (14.1%) of 74 patients. Keratoconus (28.8%) was reported as the most common indication. For the occurrence of hypertension, the average time was 9.8 months (SD 14.8) postoperatively, with an average IOP rise of 13.3 mm Hg. In 64 eyes (80%) and in 16 eyes (20%), switching of prednisolone acetate 1% to rimexolone 1% and to fluorometholone 0.1%, respectively, was done, which alone normalized IOP in 26 eyes (32.5%). At an average of 2.3 months following the switch, the achievement of an average IOP decrease of 12.3 mm Hg was noted. Since alternate topical corticosteroids provided good antiinflammatory prophylaxis with a decreased hypertensive response, therefore, these may be considered in cases of steroid-induced ocular hypertension following PKP.