Vedamurthy A, et al. - Researchers analyzed the benefits of early therapy escalation in immunosuppression-naïve patients hospitalized with severe ulcerative colitis (UC) responsive to steroids. They identified patients hospitalized with UC who were immunosuppression naïve at index hospitalization and responded to intravenous steroids, not requiring medical or surgical rescue therapy. The “therapy escalated” group included those who were initiated on immunomodulators within 3 months of hospitalization. The need for colectomy at 12 months was compared to the “not escalated” group who remained on non-immunosuppressive therapy. Investigators observed that immunosuppression-naïve ASUC patients who respond to intravenous steroids remain at risk for colectomy. It was noted that immunomodulator initiation by 3 months did not decrease the risk of colectomy at 1 year.