Cyr DP, Zih FSW, Wells BJ, et al. - Researchers followed up a cohort of 52 consecutive patients, who underwent resection of locally recurrent rectal cancer (LRRC) between 1997 and 2005, with serial exams and imaging up to the point of death, or June 30, 2019, in order to inscribe ultra-long-term (~15 years) outcomes following radical resection of LRRC. In addition, they sought relevant clinicopathologic prognostic variables. Outcomes revealed that salvage surgery for LRRC leads to achievement of exceptionally durable long-term cancer-free survival, indicating that cure is possible. Subsequent death from cancer was reported for patients with distant metastatic disease at the time of LRRC resection (n = 6), at a median of 21 months (4−46). Those without distant metastases at time of salvage surgery (n = 46) had disease-specific survival (DSS) of 47%, 38%, and 35%, respectively, at 5, 10, and 15 years; median DSS was 60 months. Superior outcomes were observed in independent correlation with negative resection margin (R0). Patients with M0 disease who had R0 resection (n = 37) exhibited DSS of 58%, 47%, and 44% at 5, 10 and 15 years, respectively; median DSS was 73 months.