Danchin N, Farnier M, Zeller M, et al. - Since an inclination to develop acute myocardial infarction (AMI) at a younger age has been reported in patients with familial hypercholesterolemia (FH), researchers analyzed a large multicenter cohort of patients to evaluate 5-year outcomes post-AMI according to the presence of FH. They used the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction, which incorporates nationwide surveys recruiting patients over a 1- to 2-month duration every 5 years. The use of an adapted Dutch Lipid Clinic score revealed the presence of probable/definite FH in 2.8% of 5,147 patients who were discharged alive and in whom FH status could be evaluated. Relative to non-FH patients, FH patients were found to have a twice high risk of long-term mortality and cardiovascular events, when adjusted on baseline features, this was true even for those taking high-intensity lipid-lowering therapy. These patients require additional treatment measures.