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Long-term outcome after first intestinal resection in pediatric-onset Crohn's disease: A population-based study

Inflammatory Bowel Disease Oct 18, 2019

Boualit M, Salleron J, Turck D, et al. - Researchers analyzed a population-based cohort (1988–2004) of 404 individuals (0–17 years) of which 130 had surgery to characterize long-term postoperative evolution of pediatric-onset Crohn's disease (CD) and determine predictors of outcome. They used regression to study the impact of time of first surgery on nutritional catch-up. A total of 130 patients with a median age at diagnosis of 14.2 years (interquartile range: 12–16) were followed for 13 years (9.4–16.6). Data reported that a second resection probability was 8%, 17%, and 29% at 2, 5, and 10 years, respectively. An increased risk of the second resection was linked to age < 14, stenosing (B2) and penetrating (B3) behaviors and upper gastrointestinal location (L4) at diagnosis in multivariate analysis. In this pediatric-onset CD study, mainly conducted in a prebiologic era, a first surgery performed within 3 years of the diagnosis of CD was related to a lessened need for IS and biologics and a better catch-up in height and weight compared with later surgery.
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