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Long-term neurological outcomes in out-of-hospital cardiac arrest patients treated with targeted-temperature management

Resuscitation Sep 27, 2018

Caro-Codón J, et al. – Investigators examined out-of-hospital cardiac arrest (OHCA) patients treated with targeted-temperature management for long-term cognitive and functional outcomes, prognostic factors that could be assessed during initial admission, and the usefulness of classic neurological scales. Among patients admitted due to OHCA from August 2007 to November 2015 and surviving ≥ 1 year, a significant proportion developed new memory-related disorders, depressive symptoms, aggressive/uninhibited behavior, and emotional lability, indicating a high prevalence of long-term cognitive deficits and functional limitations. For the development of cognitive impairment, a greater number of weekly hours of intellectual activity and a qualified job were independent protective factors. However, researchers found that being older at the time of the cardiac arrest may be a poor prognostic factor. Most of the deficits identified were not detected using the common clinical scales utilized in clinical practice.

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