Wang C, Johansson ALV, Rodriguez-Wallberg KA, et al. - Researchers examined if adolescents and young adults conceived with assisted reproductive techniques (ARTs) are at risk of psychiatric disorders owing to adverse effects of the treatment or parental background factors.

• Researchers conducted long-term follow-up of a Swedish birth cohort of 1,221,812 children (48.6% female, 51.4% male; 31,565 (2.6%) conceived with ART).

• Risk of obsessive-compulsive disorder (OCD), but not of any other types of anxiety, depression, or suicide, was recorded to higher among those conceived with assisted reproductive techniques relative to all other children.

• Differences in parental characteristics, including the underlying infertility, rather than the ART intervention itself, were noted to be responsible for the observed differences in risk.

• There appeared no association of the type of fertilization (standard IVF or ICSI) with outcomes.

• A lower risk of mood disorders was observed in correlation with fresh but not frozen embryo transfer when compared with children from couples with infertility who conceived without ARTs, indicating frozen embryo transfer as less beneficial in direct comparison with fresh embryo transfer.