Papunen S, Auvinen J, Bloigu A, et al. - This longitudinal study with a 12-year follow-up revealed that prediabetes was linked with cognitive decline during aging.

• A total of 714 individuals, followed from the age 55 to 70 years, were included.

• Employing oral glucose tolerance tests, participants were grouped as normoglycemic and based on WHO diagnostic criteria for diabetes and prediabetes.

• Significantly greater decline on the verbal fluency (category) test was detected in participants with long-lasting prediabetes vs the normal group.

• Relative to the normal group, long-lasting type 2 diabetes cases exhibited significantly greater decline (13 vs 6 s) on the trail making A test and on the wordlist learning test (3.3 vs 1.7 words).

• Significantly greater cognitive decline in the verbal fluency (category) test was seen in a combined population with prediabetes or incident type 2 diabetes, vs normal group.