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Long-term colorectal cancer incidence after adenoma removal and the effects of surveillance on incidence: A multicentre, retrospective, cohort study

Gut Aug 13, 2020

Cross AJ, Robbins EC, Pack K, et al. - A multicentre, retrospective, cohort study was performed to evaluate long-term colorectal cancer (CRC) incidence after adenoma removal and the impact of surveillance on incidence. Researchers included a total of 33,011 patients who had undergone colonoscopy with adenoma removal at 17 UK hospitals, largely (87%) from 2000 to 2010. Impact of surveillance on incidence of CRC adjusted for patient, procedural, and polyp features were calculated via Cox regression with time-varying covariates. There were 28,972 patients included in this analysis, with 14,401 (50%) classed as low-risk, 11,852 (41%) as intermediate-risk and 2,719 (9%) as high-risk. With a single surveillance visit, CRC incidence was 40%–50% lower than with none. CRC risk was lowered with surveillance after polypectomy, though the data revealed that CRC risk in some low-risk and intermediate-risk patients is not greater than what is seen in the general population, even without surveillance. Screening rather than surveillance could be appropriate in managing these patients.

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