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Long-term colorectal cancer incidence after adenoma removal and the effects of surveillance on incidence: A multicentre, retrospective, cohort study

Gut Jan 24, 2020

Cross AJ, Robbins EC, Pack K, et al. - Researchers conducted this multicentre, retrospective, cohort study to investigate colorectal cancer (CRC) incidence and impacts of surveillance on incidence in low-risk, intermediate-risk, and high-risk groups. The sample consisted of 33,011 individuals who had colonoscopy with adenoma removal at 17 UK hospitals, mostly (87%) from 2000 to 2010. Twenty-eight thousand nine hundred seventy-two patients (14,401 were classed as low-risk, 11,852 as intermediate-risk and 2,719 as high-risk) were available for analysis after exclusions. CRC incidence per 100,000 person-years was 140, 221 and 366, respectively, in the low-risk, intermediate-risk and high-risk groups. According to findings, postpolypectomy surveillance decreases risk of CRC. However, CRC risk in some low-risk and intermediate-risk patients, even without surveillance, is no higher than in the general population. Such individuals could be managed through screening rather than surveillance.
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