Zhou A, et al. - Researchers used data from the UK Biobank, as well as logistic regression, to examine whether the link between habitual coffee consumption and cardiovascular disease (CVD) risk varied with CYP1A2 (a functional variant at cytochrome P450 1A2) genotype or a genetic score for caffeine metabolism (caffeine-GS). They analyzed data for 347,077 individuals, with 8,368 incident CVD cases. An elevated CVD risk was reported for nondrinkers, drinkers of decaffeinated coffee, and those who reported drinking >6 cups/day vs those drinking 1–2 cups/day (increase in odds by 11%, 7%, and 22%, respectively). A modest increase in CVD risk was observed in association with heavy coffee consumption, but genetic variants affecting caffeine metabolism had no impact on this link.