Pinsky P, et al. - Researchers investigated an association of non-calcified nodules (NCNs) with long-term lung cancer risk that may provide indirect evidence of some NCNs being cancer precursors. Low-dose CT (LDCT) was undertaken among LDCT arm participants in the National Lung Screening Trial at baseline and years 1-2. They examined the association between NCNs located on LDCT screens and subsequent lung cancer diagnosis over different time periods at the person and lobe level. Baseline LDCT screening was performed on 26,309 participants. Lung cancer was diagnosed in 1,675 patients over a median follow-up of 11.3 years. The analysis suggests an association of the presence of nodules on low-dose CT screening with a heightened risk of lung cancer up to 12 years later. Lung cancers diagnosed even more than 4 years after nodule detection tended to occur in the same lung lobe as the nodule. Based on the size and attenuation of nodules, differences were noted in long-term lung cancer risk.