Ernst ME, Fravel MA, Webb KL, et al. - Persons with higher blood pressure variability (BPV) were more commonly found to have chronic kidney disease (CKD) and markers of decreased renal function; however, findings showed no impact of BPV on the trajectory of decline in kidney function over time in older adults who were in generally good health.

• Participants aged ≥70 years ( ≥65 if US minority) from ASPirin in Reducing Events in the Elderly (ASPREE) trial were analyzed.

• Of 6,759 participants, 1,829 (27.2%) developed incident CKD.

• In BPV tertiles 2 (27.4%) and 3 (28.3%), incident CKD occurrence was more common than in tertile 1 (25.5%); however, the risk was not significantly elevated post-covariate adjustment.

• Evaluation of estimated glomerular filtration rate (eGFR) (n=16,193) and log albumin-creatinine ratio (log ACR) trajectories (n=15,213) demonstrated participants in the highest BPV tertile exhibiting the lowest eGFR and highest log ACR, cross-sectionally.

• Across BPV tertiles, no difference was evident in the trajectories of eGFR and log ACR.