Viazzi F, et al. - In patients with type 2 diabetes (T2D) and hypertension, researchers evaluated the link between visit-to-visit systolic blood pressure (SBP) variability and the development of chronic kidney disease (CKD). Participants included 30,851 patients with T2D and hypertension, with normal estimated glomerular filtration rate (eGFR). The investigators analyzed participant clinical records and 4-year follow-up data. Using three metrics, evaluation of SBP variability was done: coefficient of variation, SD of the mean SBP, and average absolute difference of successive values in each individual. CKD was defined as eGFR < 60 and/or a reduction in eGFR ≥ 30% from baseline. The clinical characteristics that were associated with the intraindividual SBP variability were older age, male sex, SBP, diastolic BP, albuminuria, glycated hemoglobin, and insulin treatment. In patients with T2D and hypertension, CKD was predicted by increased long-term BP variability.