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Long‐term PM2.5 exposure and risks of ischemic heart disease and stroke events: Review and meta‐analysis

Journal of the American Heart Association Jan 06, 2021

Alexeeff SE, Liao NS, Liu X, et al. - Researchers performed a review and meta‐analysis to quantitatively summarize studies regarding long‐term exposure to fine particulate matter < 2.5 µm in diameter (PM2.5) and risk of ischemic heart disease (IHD) and stroke events. Studies published by December 31, 2019 with myocardial infarction, stroke, IHD mortality, and cerebrovascular mortality as main outcomes were included and analyzed. A total of 69 studies were reviewed and 42 studies were included in the meta‐analyses. As per findings, increased risks of IHD mortality, cerebrovascular mortality, and incident stroke were observed in relation to long‐term PM2.5 exposure. The association with incident myocardial infarction is indicative of raised risk but not conclusive. There is a requirement for more research in order to understand the link with recurrent events. A 10‐µg/m3 increase in long‐term PM2.5 exposure correlated with an increased risk of 23% for IHD mortality, 24% for cerebrovascular mortality, 13% for incident stroke, and 8% for incident myocardial infarction. 

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