Budweiser S, Tratz F, Gfüllner F, et al. - Researchers determined the long‐term result of Obesity Hypoventilation Syndrome (OHS) with a special focus on pulmonary hypertension (PH), given PH represents a common comorbidity in OHS. This inquiry was performed using a prospective design. In this study, 64 patients with OHS and established non‐invasive positive pressure ventilation (NPPV), were evaluated by serum biomarkers, right‐heart catheterization, blood gases analysis, lung function, Epworth‐Sleepiness Scale, Pittsburgh Sleep‐Quality‐Index, World Health Organization‐functional class and health‐related quality of life (HRQL) through the Severe Respiratory Insufficiency questionnaire. Re-evaluation of participants was done after a planned follow‐up of 5 years. Findings revealed worsening of HRQL despite a high long‐term NPPV use. It was noted that age, oxygen use at baseline, diffusion capacity for carbon monoxide (DLCO, %pred) and NT‐proBNP, as a proxy parameter for PH, were associated with long‐term survival.