Liu J, Liu F, Fang Q, et al. - Researchers conducted this prospective observational study to evaluate long‐term donor site morbidity after radial forearm free flap harvesting. Participating patients were asked to complete the Disability of the Arm, Shoulder, and Hand (DASH) questionnaire and to undergo wrist motion and hand strength examinations at different time points. The data were prospectively gathered and retrospectively analyzed. Up to 24 months after the operation, the postoperative DASH score did not return to normal. Compared with the preoperative level, the mean postoperative wrist motion degree of flexion was significantly decreased and returned to normal at 12 months following surgery. In terms of extension, radial abduction, and ulnar abduction, similar patterns were noted. Compared with the preoperative level, the mean postoperative grip strength was significantly reduced and remained dysfunctional at 24 months after the operation. In regard to tip pinch and key pinch, a similar pattern was also noted. The long-term negative impact on hand strength is maintained.