Kastelik J, et al. - In this two-group randomised, controlled clinical trial, researchers assessed two analgesic regimens for total knee arthroplasty (TKA) viz, local infiltration anaesthesia (LIA) vs analgesia based on an adductor canal catheter and a single-shot sciatic nerve block, focusing on mobility, postoperative pain and patient satisfaction. Eligible participants were adults undergoing primary TKA under general anaesthesia. Those with heart insufficiency (New York Heart Association class >2), liver insufficiency (Child Pugh Score >B), evidence of diabetic polyneuropathy, severe obesity (BMI > 40 kg m−2), chronic opioid therapy for more than 3 months before scheduled surgery and allergy to local anaesthetics were excluded from the trial. Early mobilisation after TKA with high patient satisfaction were achieved with both analgesic regimens. LIA patients exhibited higher maximum postoperative pain scores on exertion, with a mean 1.3 of 10 numerical rating scale points, as well as higher intra-operative opioid needs. LIA patients had attenuated anaesthesia induction time.