Xu G, Zhou CS, Tang WZ, et al. - Researchers examined the efficacy of local methylcobalamin injection for subacute ophthalmic herpetic neuralgia (SOHN) via performing a single‐center randomized controlled study including 105 patients with a pain score of 4 or greater. Participants were administered a combination of methylcobalamin and lidocaine via local injection (LM group, n  = 35), intramuscular methylcobalamin and local lidocaine injection (IM group, n  = 35), or oral methylcobalamin tablet and lidocaine local injection (OM group, n  = 35) for 4 weeks. All groups showed reduction in pain scores, however, the LM group had significantly greater reduction (6.7 at baseline vs 2.8 at endpoint) compared with systemic administration (IM group 6.8 vs 4.9, OM group 6.7 vs 5.1). Further, the LM group had significantly reduced analgesic use (94% at baseline vs. 6% at endpoint) and had higher health‐related quality of life than the systemic groups. In mixed modelling, a lower response to methylcobalamin was observed in correlation with increased age.