Fricker ZP, et al. – In this study, researchers investigated whether people with hepatic steatosis—without a clinical diagnosis of liver disease—have higher serum levels of systemic inflammation and oxidative stress markers. Using data collected from 2,482 participants of the Framingham Heart Study who underwent computed tomography and measurement of 14 serum markers of systemic inflammation, they performed data analysis. Multivariable linear regression models were used to evaluate the correlation between liver fat and systemic inflammatory markers. The following inflammatory markers were related to liver fat in multivariate-adjusted models: high-sensitivity C-reactive protein, urinary isoprostanes, interleukin 6, intercellular adhesion molecule 1 and P-selectin. Findings suggested that individuals with hepatic steatosis without known liver disease had higher mean serum concentrations of systemic markers of inflammation in a community-based cohort.