Verdecchia NM, Rodosky MW, Kentor M, et al. - A randomized, double-blind, placebo-controlled trial was designed to correlate liposomal bupivacaine to an equivalent volume of saline injected into the subacromial space and arthroscopy portal sites in patients undergoing rotator cuff repair under interscalene block with sedation. The Numeric rating pain score at the time of block resolution, as reported during the follow-up phone call on postoperative day one was the primary outcome measure. The mean pain scores at rest as well as oral morphine equivalent requirements on postoperative days 1, 2, and 3 were considered as secondary outcomes. No statistically significant variations were observed in the primary outcome of numeric rating pain scores on the resolution of the interscalene nerve block, nor in those reported on postoperative days 1 or 2. Though opioid consumption and patient satisfaction score did not differ between groups, there was a minor but statistically significant variation in mean resting pain scores on day 3. No difference was found in reported mean pain scores among the groups in those instructed to perform passive range-of-motion exercises.