Lee H, Park KS, Jeon YJ, et al. - Findings demonstrate an association of higher lipoprotein(a) (Lp[a]) level with subclinical coronary atherosclerosis among asymptomatic individuals undergoing coronary computed tomographic angiography (CCTA).

• This large cross-sectional study included 7,201 asymptomatic people who voluntarily underwent CCTA as part of a general health examination.

• Total 2,557 (35.5%) participants had any coronary plaque detected on CCTA; calcified, non-calcified, and mixed plaques were present in 33.5%, 5.0% and 3.5%, respectively.

• Post-adjustment for cardiovascular risk factors, the fourth Lp(a) quartile was significantly related to any coronary (odds ratio [OR] 1.212), calcified (1.205), non-calcified (1.588), or mixed (1.674) plaque relative to the first Lp(a) quartile.

• The fourth quartile had a higher odds ratio for significant stenosis (1.537) than the first quartile.