Wei JJ, et al. - Uterine serous carcinoma represents a high grade as well as an aggressive type of endometrial malignancy with a characteristic histologic, molecular, and clinical presentation. A better understanding of the basis for the observed racial disparity for uterine cancer outcomes is needed.

• Uterine serous carcinoma is responsible for 10% of uterine cancers, but 40% of disease death.

• A 2- to 4-fold higher incidence of aggressive endometrial cancer subtypes, specifically of uterine serous carcinoma, has been noted in African American (AA) women vs non-Hispanic (NH) White women, which could partly explain the worse survival results for uterine cancer in AA females.

• Known risk factors for poorer cancer outcomes include clinical factors (e.g., obesity, diabetes, hypertension, and age at diagnosis) and socioeconomic conditions.

• Other likely contributors to the survival disadvantage among AA women include tumor biology, molecular alterations, and other epigenetic features.