Chen L, et al. - An appraisal was performed of the effects of light-emitting diode (LED) photomodulation (585 nm) on melanogenesis in human epidermal melanocytes (HEMs). The melanin content was suppressed by the LED photomodulation with 585 nm wavelength, in HEMs. The effect was attributed to its dose-dependent inhibition on melanogenesis and the induction of HEMs autophagy. New insights could be yielded with regard to the efficacy of LED photomodulation in the treatment of hyperpigmentation disorders.