Leon-Acuña A, Torres-Peña JD, Alcala-Diaz JF, et al. - Researchers focused on the effect of regular alcohol consumption, physical activity and smoking habit modulating postprandial hypertriglyceridemia (PPT) in the CORDIOPREV study. They obtained serial blood samples at 0, 1, 2, 3 and 4 h during postprandial state from 1,002 patients subjected to an oral fat load test meal. A detrimental response is a PPT level above 2.5 mmol/L (220 mg/dL) at any time point. In the current, recent ex-smokers, long-term ex-smokers, and in never smokers, the prevalence of undesirable PPT response was estimated to be 68%, 58%, 49%, and 48%, respectively. They found higher PPT response as well as a greater AUC and higher incremental of triglycerides in current and recent ex-smokers vs long-term ex-smokers and never smokers, with no differences seen among these subgroups. Overall, smoking was identified as an independent risk factor modulating PPT magnitude. However, a progressive reduction in PPT among ex-smokers was seen after tobacco discontinuance that reached levels similar to those of never smokers. Based on regular physical activity or alcohol consumption habits, there were no differences in the magnitude of PPT.