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Life course changes in cardiometabolic risk factors associated with preterm delivery: The 30‐Year CARDIA Study

Journal of the American Heart Association Aug 10, 2020

Sun B, Bertolet M, Brooks MM, et al. - This is the first study examining the life course patterns of cardiometabolic risk factors among women with preterm deliveries as opposed to women with term deliveries, maintaining the temporality of change in the risk factor in relation to the childbearing years of each woman. In the CARDIA (Coronary Artery Risk Development in Young Adults) study, 1,306 women (51% Black) with births between baseline (1985–1986) and year 30 were identified. Using piecewise linear mixed‐effects models, the authors contrasted life course changes in blood pressure, BMI, waist circumference, and lipids in women with preterm deliveries (n = 318) with those with all term deliveries (n = 988). Findings suggested an association of preterm delivery with unfavorable patterns of change in diastolic blood pressure and adiposity that occur during the childbearing years and that continue or worsen later in life. Such adverse changes can lead to increased cardiovascular risk among women with preterm delivery.

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