Redman B, Kitchen C, Johnson KW, et al. - The results demonstrate that testosterone plays a major role in the sexual side effects reported by men taking antipsychotics, Although there is a need for larger studies to further categorize this association.

• Researchers conducted a pilot study to explore the prevalence of elevations in prolactin levels, related reductions in testosterone levels, associated symptoms of sexual dysfunction and breast abnormalities in male participants, and related distress to these symptoms in men taking prolactin-elevating antipsychotic medications.

• This was a cross-sectional study.

• The findings revealed a notably high prevalence of sexual side effects in this population, with gynecomastia occurring in 50% and penile-related symptoms in 73%.

• They further observed increased prolactin levels in 68% and low testosterone levels in 55% of our participants.

• Due to a small sample size of 22 men and the lack of a control group, this study was limited in its power.

• As per the results, a trend of hyperprolactinemia being associated with low testosterone and a significant correlation of low testosterone levels with penile-related symptoms, even in our relatively small sample.