Tadic M, et al. – In this present study, the researchers assessed left atrial (LA) phasic function and heart rate variability (HRV) in patients with uncomplicated systemic sclerosis (SSc). They applied both volumetric and strain method, as well as cardiac autonomic nervous function and concluded that left atrial (LA) phasic function was significantly deteriorated in SSc patients. Skin score and HRV indices correlated with LA phasic function parameters.

Methods

• This study enrolled 44 SSc patients and 33 age–matched healthy controls. 
• All participants underwent clinical examination, serological tests, 24–hours Holter monitoring, and echocardiographic examination including strain analysis.

Results

• In the SSc patients, maximum, minimum, and pre–A LA volumes and volume indices were higher compared to the controls. 
• The total emptying fraction, the parameter of the LA reservoir function, as well as passive LA emptying fraction, which represents the LA conduit function, were significantly lower in the SSc patients compared to the controls.
• In the SSc participants, active LA emptying fraction, the parameter of the LA booster pump function, was significantly higher.
• There was no difference in LA reservoir function between the diffuse and the limited SSc form. 
• LA conduit function was significantly decreased, whereas LA booster pump function was compensatory increased in the diffuse SSc form compared to the limited SSc form.
• With LA strain analysis, similar results were obtained.
• In the SSc patients, HRV indices were significantly decreased.
• Modified Rodnan skin score, the parameter of skin involvement in SSc, and HRV indices correlated well with LA phasic function in SSc.