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Leber hereditary optic neuropathy: Bridging the translational gap

Current Opinion in Ophthalmology Sep 15, 2017

Jurkute N, et al. - Here, researchers address the clinical evolution of the disease, the secondary etiological factors that could contribute to the visual loss, and the challenging task of developing effective treatments. Leber hereditary optic neuropathy (LHON) is phenotypically more heterogeneous than previously considered and a complex interplay of genetic, environmental and hormonal factors modulates the risk of a LHON carrier losing vision. Advances in disease modelling, drug screening and genetic engineering offer promising avenues for therapeutic breakthroughs in LHON.
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