Gudjonsdottir MJ, Hentz E, Adlerberth I, et al. - Researchers conducted the study for evaluating the epidemiology of late-onset (LO) neonatal invasive infections with surveillance covering 43 years, starting from 1975. The sample consisted of infants born in western Sweden in 1997–2017, who had positive blood and cerebral spinal fluid culture between 3 and 120 days of age. A total of 473 cases of LO infection in 437 patients were reported. Around 1997–2007 and 2008–2017, the incidence increased from 2.0 to 3.1/1000 live births (LB). Among infants born < 28 weeks gestation, the increase in incidence was most pronounced. Staphylococcus aureus, coagulase-negative staphylococci, and Escherichia coli were the most frequent pathogens. During the study period (1997–2017), the incidence of LO neonatal invasive infections increased, but the case-fatality rate remained lower than in the previous surveillance period (1975-1996). In order to combat the rising occurrence of high-risk infants, more monitoring and strategies with an emphasis on prevention are crucial.