Mackin RS, Insel PS, Landau S, et al. - To ascertain the role of cortical amyloid deposition as a factor contributing to memory dysfunction as well as increased risk of dementia related to late life depression (LLD), this investigation was carried out among 119 older adult patients with current diagnosis of Major Depression (LLD) from the ADNI Depression study as well as 119 non-depressed (ND) cognitively unimpaired people matched on age, gender, and APOE genotype collected from the ADNI database. Researchers found a correlation between global Aβ and worse memory performance. Contrary to expectation, less Aβ deposition was detected in the LLD group vs ND, and Aβ deposition was not related to depression history features. A link was identified between Aβ and memory but this link did not vary between LLD and ND. Based on these findings, it was inferred that greater cortical Aβ accumulation is not responsible for the observed memory deficits and accelerated cognitive decline in previous studies of late life depression.