Yamashita T, et al. - In patients with severe acute pancreatitis (SAP), researchers assessed the correlation between the volume of fluid administered and clinical results. The criteria for inclusion were 18 years of age or older and were diagnosed with SAP between 2009 and 2013. For this multicenter retrospective study, subjects were stratified into two groups: administered fluid volume <6000 and ≥6000 mL in the first 24 hours. Using multivariable logistic regression analysis, the association between the two groups and clinical results were evaluated. Data reported that overall in-hospital mortality was 12.3%. Compared to the fluid <6000 mL group, the fluid ≥6000 mL group had significantly higher mortality. There was no significant association between the administered fluid volume and pancreatic infection or between the volume administered and the need for surgical intervention. Overall, the investigators concluded that the administration of a large fluid volume within the first 24 hours was related to reduced mortality in patients with SAP.