Bellocchi C, Ying J, Goldmuntz EA, et al. - This study was intended to explore a large‐scale assessment of serum protein dysregulation in diffuse cutaneous systemic sclerosis (dcSSc) and to evaluate serum protein correlates of SSc fibrotic features. Researchers assessed serum protein profiles of 66 participants with dcSSc at baseline who were enrolled in the Scleroderma: Cyclophosphamide or Transplant Trial and 66 age‐ and gender‐matched healthy control subjects. They evaluated a panel of 230 proteins, including several cytokines and chemokines. The data exhibited that diffuse cutaneous SSc has a distinct serum protein profile with prominent dysregulation of proteins related to fibrosis and immune cell adhesion/diapedesis. The findings reveal that in SSc, the differential expression for most serum proteins is likely to originate outside the peripheral blood cells.