Helou DG, Shafiei-Jahani P, Hurrell BP, et al. - This study was carried out to evaluate the expression of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and analyzed its role in human and murine type-2 innate lymphoid cells (ILC2s). In this analysis, WT and LAIR-1 KO mice were intranasally challenged with IL-33 and pulmonary ILC2s were sorted to conduct an ex-vivo comparative study, based on RNA sequencing and flow cytometry. Researchers used Knockdown antisense strategies and humanized mice to evaluate the role of LAIR-1 in human ILC2s. The outcomes unravel a novel regulatory axis in ILC2s with the capacity to decrease allergic AHR and lung inflammation.