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Lactate and hypotension as predictors of mortality after in-hospital cardiac arrest

Resuscitation Oct 26, 2020

Issa MS, Grossestreuer AV, Patel H, et al. - Researchers undertook this single center retrospective observational study to assess whether hospital mortality could be predicted by lactate and need for vasopressors after in-hospital cardiac arrest (IHCA). For this purpose, they used multivariate logistic regression. This analysis involved 364 patients in total. Significantly higher mortality was noted in patients who received vasopressors within 3 h post-return of spontaneous circulation (ROSC) vs in those who did not receive vasopressors. A link of increased lactate level with mortality was also identified (44% if lactate < 5 mmol/L, 58% if lactate 5–10 mmol/L, and 73% if lactate > 10 mmol/L). Overall, it was concluded that in patients needing mechanical ventilation post-IHCA, risk of mortality may be stratified based on post-ROSC lactate and need for vasopressors.

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