Hu N, Liu D, Zhao N, et al. - This study was undertaken to investigate if TNF polymorphism is correlated with ankylosing spondylitis (AS) susceptibility in human leukocyte antigen (HLA)-27-positive population. Researchers carried out searches of Pubmed, Embase, and Cochrane databases (up to March 2020). They presented pooled and individual odds ratios with 95% confidence intervals of the minor allele of each locus to evaluate the correlations between TNF polymorphisms and AS in HLA-B27-positive population. This meta-analysis enrolled ten studies from ten articles. No relationship of the TNF polymorphisms with AS was found in the HLA-B27-positive AS group and HLA-B27-positive control group. The outcomes indicated that in the HLA-B27-positive AS patients and random control population, polymorphisms of TNF-238, -308, -857, -1031, -863 were correlated with AS susceptibility. In the HLA-B27-positive population, other gene SNPs except TNF may play an important role in AS susceptibility.