Feurer E, et al. - Via performing cross-sectional and longitudinal analyses from the OFELY Cohort, researchers analyzed the serum levels of 32 preselected miRNAs with reported function in bone and their connection with osteoporotic fracture. qRT-PCR quantified serum levels of miRNAs in 682 women: 99 premenopausal and 583 postmenopausal women, with 1 and 122 women in each group having prevalent fragility fractures. A number of miRNAs were noted to be connected with fragility fractures (prevalent or incident), bone turnover markers (BTMs), BMD, and microarchitecture. The authors found no evidence in a well-characterized prospective cohort with a sizeable sample size that these 32 preselected miRNAs were not linked to BTM, BMD, microarchitecture and/or fragility fractures.