Igarashi Y, et al. – In this work, the performance of two multiplex, real–time PCR tests (Anyplex II MTB/MDR and MTB/XDR; Seegene, Seoul, Korea), designed to detect the Mycobacterium tuberculosis complex (MTC) and drug–resistance mutations associated with isoniazid, rifampicin, fluoroquinolones, and second–line injectable drugs was evaluated. Findings suggest that the Anyplex II kits could be useful as rule–in tests for detecting MTC and drug resistance.