Wallace IJ, Felson DT, Worthington S, et al. - Researchers proposed that knee osteoarthritis is one such disease for which perceptivity is magnified by the energy balance transition. Irrespective of having considerably lower obesity levels than the Americans, the Tarahumara seem predisposed to accrue greater abdominal adiposity (ie, larger abdomens) for given body weight and are more vulnerable to radiographic and symptomatic knee OA at lower levels of BMI. Moreover, proportionate increases in the abdomen size in the two groups were correlated with greater rises in radiographic knee OA risk among the Tarahumara than the Americans, suggesting that the abdominal adipose tissue of the Tarahumara is a more predominant stimulus for knee degeneration. Thus, among non-industrial societies encountering hurried lifestyle modifications, increased vulnerability to knee OA is a matter of concern that guarantees additional examination since such groups designate a large but understudied fraction of the worldwide population.