Eaton EF, et al. - In view of the decline in antiretroviral therapy (ART) durability, time to modification, or cessation, researchers examined how kidney dysfunction contributes to this reduced durability. They evaluated 4,515 treatment-naive people living with HIV initiating ART in this retrospective follow-up study of CNICS between 2007 and 2014. ART modification was seen in 1,967. Modification was required in 1,580 (41%) of 3,888 of patients receiving TDF-based ART vs 387 (62%) patients receiving other regimens. The findings revealed no major effect of kidney dysfunction on regimen modification for patients initiating ART, including TDF-based ART, in the last decade.