Chen Y, Zelnick LR, Wang K, et al. - Given that the secretion of organic solutes by the proximal tubules represents an important intrinsic kidney function, so, researchers focused on the clinical significance of the kidney’s clearance of tubular secretory solutes in this prospective cohort investigation with 3,416 CKD patients who took part in the Chronic Renal Insufficiency Cohort (CRIC) study. Experts assessed plasma and 24-hour urine levels of endogenous candidate secretory solutes at baseline, employing targeted liquid chromatography–tandem mass spectrometry. Findings revealed a link between lower kidney clearances of endogenous secretory solutes and CKD progression as well as all-cause mortality, this link was independent of eGFR and albuminuria. This implies that additional information regarding kidney health is afforded by tubular clearance of secretory solutes, beyond measurements of glomerular function alone.