Gamble JJ, et al. - Researchers tested their hypothesis that ketamine-based anesthesia for electroconvulsive therapy (ECT) results in superior improvement in treatment-resistant major depressive disorder (MDD) outcomes compared with propofol-based anesthesia. They used a modified intention-to-treat analysis to compare the primary outcome (the median number of ECT treatments required to achieve a 50% reduction) and secondary outcome [a score ≤ 10 on the Montgomery-Asberg depression rating scale (MADRS)] between the anesthesia groups. They found that ketamine-based anesthesia vs propofol-based anesthesia provided response and remission after fewer ECT sessions in this early-terminated small-sized study. They also reported similar adverse events and recovery time between groups.