Baekgaard JS, et al. - Researchers compared ketamine to other agents (etomidate, propofol, thiopental, or midazolam) for rapid sequence induction (RSI) in trauma patients. They performed a systematic review of relevant studies identified from PubMed, Embase, and the Cochrane Library, reporting 30-day mortality as the primary outcome and blood transfusions, length of hospital stay, and hospital mortality as secondary outcomes. They analyzed a total of 4 studies and evaluated the bias risk with the Cochrane Risk of Bias assessment tool for randomized trials and the Risk of Bias in Non-Randomized Studies of Interventions for nonrandomized studies of intervention. They found this topic has been addressed in extremely few studies. Compared to other induction agents, induction with ketamine did not result in significantly differed outcomes in terms of mortality, length of hospital stay, or number of blood transfusions, however, a clinically relevant benefit or harm could not be excluded.