Bai JDK, Babu S, Roa-Pena L, et al. - The present study was undertaken to investigate whether K17 mRNA and protein levels associated with reduced survival of individuals with high-grade endometrial cancer. From The Cancer Genome Atlas, gene expression data (mRNA) were examined for 271 high-grade endometrial carcinomas and K17 immunohistochemistry (IHC) was conducted on a separate cohort of 119 high-grade endometrial cancer cases from two academic medical centers. Cox proportional hazards regression ascertained survival analysis. The evidence showed that high K17 mRNA and IHC associated with decreased overall survival. In malignant glandular cells of the endometrium, K17 was positive but not in other tissues, involving endometrial stroma, myometrium, and uterine sarcoma. These outcomes confirm the result that K17 is a negative prognostic biomarker in high-grade endometrial carcinoma and that K17 IHC test results could be applied to inform decisions related to therapeutic intervention.